Are Sequence Family Variants Useful for Identifying Deletions in the Human Y Chromosome?
نویسندگان
چکیده
منابع مشابه
Are sequence family variants useful for identifying deletions in the human Y chromosome?
DELETION RESULT AT STS a sY142 sY1197 sY1191, sY1192, and/or 50f2/C sY1291 sY1206 sY1201 b2/b3 b ϩ ϩ Ϫ ϩ ϩ ϩ gr/gr ϩ ϩ ϩ Ϫ ϩ ϩ b1/b3 ϩ Ϫ Ϫ Ϫ ϩ ϩ b2/b4 c ϩ ϩ Ϫ Ϫ Ϫ ϩ None ϩ ϩ ϩ ϩ ϩ ϩ NOTE.—See Kuroda-Kawaguchi et al. a ϩ p present; Ϫ p absent. b Termed the " g1/g3 " deletion by Fernandes et al. (2004). c " Classical " AZFc. To the Editor: We read with interest the report of a novel deletion of p...
متن کاملMSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome
Y chromosome deletions arise frequently in human populations, where they cause sex reversal and Turner syndrome and predispose individuals to infertility and germ cell cancer. Knowledge of the nucleotide sequence of the male-specific region of the Y chromosome (MSY) makes it possible to precisely demarcate such deletions and the repertoires of genes lost, offering insights into mechanisms of de...
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It is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the Y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (AZF) in Yq 11.23. However, it is not known whether Yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (o...
متن کاملMolecular Study of Partial Deletions of AZFc Region of the Y Chromosome in Infertile Men
Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...
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The success of the Human Genome Project (HGP) has provided a blueprint for the approximately 20,000 gene-encoded proteins potentially active in all of the hundreds of cell types that make up the human body. Yet we still have limited knowledge about a majority of the gene-encoded proteins which are the “building blocks of life” and “cellular machinery”. It is estimated that for nearly half of th...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2004
ISSN: 0002-9297
DOI: 10.1086/423394